Multi-b-values-fitting readout-segmentation of long variable echo-trains diffusion-weighted imaging (RESOLVE DWI) in evaluation of disease activity and curative effect of axial spondyloarthritis (axSpA)

Background Disease activity is relevant to the treatment and prognosis of axSpA, methods quantitatively assess disease efficacy axSpA are still being explored. Objective The purpose this study was find an optimal quantitative indicator for evaluating curative effect using multi-b-values-fitting RESOLVE DWI. Methods prospective included 106 patients divided into group (n=89) no-axSpA (n=17) by Assessment Spondyloarthritis international Society (ASAS) criteria. were active inactive according ASDAS-CRP. treated with systematic tumour necrosis factor inhibitors (TNFi) selected as (n=20). All underwent MRI examination sacroiliac joints (SIJs), including ADC values subchondral bone marrow in SIJs measured (ADC 50,500 b=50,500s/mm 2 fitting, 50,700 b=50,700s/mm 50,500,700 b=50,500,700s/mm fitting). By comparing between different groups, a relatively b-values-fitting sequence obtained, further group. Resultd group, all higher than those had largest AUC, relative sensitivity specificity while taking account image quality groups. In there no significant difference pre-treatment 3 weeks, weeks 6 12 (all P>0.0083, Bonferroni-corrected threshold), decreased interval or more statistically P<0.0083, threshold). Conclusion Multi-b-values-fitting (b=50,500,700s/mm ) DWI has certain advantage axSpA. It worth noting that short-term review (3 less) unsatisfactory at later would help evaluate